Papel de la horquilla amino-terminal como elemento clave en la funcionalidad de las ribotoxinas de "aspergillus"
Bibliographic record
Abstract
Las ribotoxinas son una familia de ribonucleasas, con una característica citotoxicidad y alergenicidad. En esta Tesis Doctoral queda demostrado el papel esencial que un elemento de su estructura, la horquilla amino-terminal, juega en estas funciones. Esta región es responsable del obligatorio reconocimiento del ribosoma, necesario para la posterior inhibición de la biosíntesis de proteínas en las células diana mediante su actividad ribonucleasa específica sobre dicho sustrato. Y además, contiene epítopos que participan en la inducción de la respuesta alérgica en pacientes sensibilizados a Aspergillus. La caracterización de este elemento de las ribotoxinas ha significado un paso cualitativo a la hora de comprender el mecanismo por el cual actúan estas proteínas, y abre la puerta a su posible aplicación en el ámbito clínico.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.005 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".