Poly(ethylene glycol-co-lactic acid) block copolymer micelles : synthesis, physicochemical characterization, and degradation
Bibliographic record
Abstract
The goal of this thesis was to synthesize two poly(lactic acid)-co-poly(ethylene glycol) biodegradable amphiphilic block copolymers that can self-assemble in an aqueous environment into a micellar morphology. Also, the physicochemical characteristics of both the copolymers and resultant micelles were studied using a variety of chemical characterization techniques to gain insight into the factors that are important in the formation and function of the micelles. Two copolymers were synthesized which had different sizes and relative block lengths. These copolymers were characterized using NMR spectroscopy, gel permeation chromatography and thermogravimetric analysis. With these two polymers the self-assembly conditions which lead to the most narrow size distribution as determined by dynamic light scattering, were found and micelles were characterized by scanning electron microscopy, and through the partitioning of pyrene between the core of the micelles and water. Finally, an investigation of the time scales of micelle degradation was performed by monitoring a solution of micelles over an extended period of time.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".