Prevalence, risk factors and therapy for postpartum anestrus in dairy cows
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
This thesis is an investigation of the prevalence and risk factors for anovulatory anestrus (AA) defined as skim milk progesterone concentrations < 1 ng/ml determined at 46 and 60 ± 7 DIM, an in depth investigation of the impact of subclinical ketosis on the probability of pregnancy at first service, and time to pregnancy and the efficacy and safety of a Progesterone Releasing Intravaginal Device (P.R.I.D., 1.55 g Progesterone) in cows failing to display estrus by 60 DIM and cows diagnosed not pregnant 30-60 days after insemination. Eighteen Ontario dairy herds participated in an observational study between February 2004 and April 2005. The prevalence of AA was 19.5% (95% confidence interval = 17.4 to 21.6%) with a large amount of variation between herds (5% to 44%). This definition of AA identified a population of cows that suffered from increased time to first insemination and pregnancy than cycling herdmates. The impact of anestrus diminished over time with the rate of pregnancy becoming equivalent to herd mates after 140--160 DIM. Similarly cows that were classified as subclinically ketotic suffered reduced reproductive efficiency until approximately 140 DIM. Both the magnitude and duration of subclinical ketosis impacted the probability of pregnancy at first insemination. Classification as subclinically ketotic in the second week postpartum explained the most variation in time to pregnancy. Exogenous progesterone in lactating dairy cows that failed to display estrus followed by a single injection of prostaglandin F2[alpha] effectively synchronized estrus and reduced time to pregnancy. However, it did not improve the probability of pregnancy at first insemination. PRID treatment for 7-days within an ovulation synchronization and fixed time insemination program in cows diagnosed not pregnant increased the probability of pregnancy at first insemination and reduced time to pregnancy. Animal safety was assessed through vaginal reaction, vaginal mucosal integrity, and estimation of the immune systems response. The findings of this thesis suggest that anovulatory anestrus and subclinical ketosis early in lactation are significant risk factors for reduced cow-level fertility and exogenous progesterone is a potential therapy in these cows.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it