Prosaposin: a protein with\n\t\t\t\t differential sorting and multiple functions
Bibliographic record
Abstract
In eukaryotes the delivery of newly\n\t\t\t\t synthesized proteins to their final destination is\n\t\t\t\t dependent on a series of functionally distinct\n\t\t\t\t compartments, including the endoplasmic reticulum and\n\t\t\t\t the Golgi apparatus, which plays a role in posttranslational modification, sorting and distribution of\n\t\t\t\t proteins. Most cargo is sorted within, and exits from, the\n\t\t\t\t trans-Golgi network (TGN). Proteins delivered to\n\t\t\t\t lysosomes include hydrolytic enzymes and nonenzymic\n\t\t\t\t activator proteins. They are directed away from the cell\n\t\t\t\t surface by their binding to mannose-6-phosphate\n\t\t\t\t receptors (MPR). However, in I-cell disease, in which\n\t\t\t\t the MPR pathway is disrupted, the nonenzymic\n\t\t\t\t sphingolipid activator protein, prosaposin, continue to\n\t\t\t\t traffic to lysosomes. This observation led to discovery of\n\t\t\t\t a new lysosomal sorting receptor, sortilin. The targeting\n\t\t\t\t prosaposin to the lysosomes results from the interaction\n\t\t\t\t of its C-terminus with sortilin. Deletion of the Cterminus did not interfere with its secretion, but\n\t\t\t\t abolished its transport to the lysosomes. Mutational\n\t\t\t\t analysis revealed that the first half of the prosaposin Cterminus contains a motif required for its binding to\n\t\t\t\t sortilin and its transport to the lysosomes. Prosaposin\n\t\t\t\t can be also secreted to the extracellular space as\n\t\t\t\t oligomers. Extracellular prosaposin showed to exert a\n\t\t\t\t variety of responses in nervous tissues including the\n\t\t\t\t activation of G protein-coupled receptors and ERK\n\t\t\t\t phosphorylation. Lastly, prosaposin has been found to be\n\t\t\t\t expressed in other fluids of the body such as pancreaticjuice, bile, cerebrospinal fluid, milk and seminal fluid,\n\t\t\t\t indicating that prosaposin is not only a house keeping\n\t\t\t\t lysosomal protein but an essential factor in the\n\t\t\t\t development and maintenance of the nervous systems\n\t\t\t\t and other systems of the body.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".