The role of endogenous Cellular Communication Network factor 5 (CCN5) expression on normal β-cells growth and insulin resistance caused by diet-induced obesity
Bibliographic record
Abstract
The role of endogenous Cellular Communication Network factor 5 (CCN5) expression on normal -cells growth and insulin resistance caused by diet-induced obesity.Metabolic syndrome and diabetes mellitus are increasing rapidly recently.Pancreas regeneration and replication of -cell are some of the challenges that medical doctors and researchers face today.Cellular communication network factor 5 (CCN5) is a matricellular protein, the expression of which is under the regulation of Wnt signaling and IGF-1.Our previous characterization supports the notion that CCN5 promotes the proliferation and survival of pancreatic -cells leading to metabolic benefits.To examine the role of endogenous CCN5 in metabolism and specifically in pancreatic islets and adipose tissues we generated total CCN5 knockout mice and fed them either with a normal-chow diet or high-fat diet (HFD -60% kcal fat) for 27 weeks.Contrary to previous findings, our CCN5 knockout mice, both male and female, exhibited no significant change in lean/fat mass, insulin sensitivity, nor glucose tolerance when fed a chow
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".