The role of CBP/14-3-3 in the regulation of initiation of DNA replication in budding yeast /
Bibliographic record
Abstract
Over the past several decades, the S. cerevisiae replication system provided excellent tools to study the initiation of DNA replication, and has built basic models to understand this process in higher eukaryotes. Therefore, identification and characterization of budding yeast replication initiation proteins, and their associations with replication origins, have significantly advanced our knowledge of eukaryotic DNA replication. Taking advantage of this tool, I studied the role of the cruciform binding protein CBP/14-3-3 in the regulation of the initiation of DNA replication in the budding yeast. CBP/14-3-3 was previously identified as an origin binding protein, and both its cruciform and origin binding activities are cell cycle regulated. In this thesis, I investigated the two fundamental activities of 14-3-3 proteins involved in DNA replication, namely the cruciform binding activity and the regulation of initiation of DNA replication.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".