Role of bone morphogenetic protein in the liver
Bibliographic record
Abstract
Elevated levels of plasma homocysteine (Hcy) are believed to be involved in several health problems, including liver fibrosis. However, the mechanism of Hcy induced liver injury remains to be further investigated. Although all hepatic cell types are involved in fibrogenesis, the activation and proliferation of hepatic stellate cells (HSCs) are considered to be central events. Moreover, it is reported that bone morphogenetic proteins (BMPs) play an important role in cell proliferation, differentiation and apoptosis. In this experiment, we examined the expression of BMPs in rat liver with hyperhomocysteinemia (HHcy) and in HSC cell lines at both mRNA and protein levels. The principal findings suggest that the expression of BMP-13 was significantly reduced in the liver of rats after 4 and 12 weeks of HHcy compared with that in control. Furthermore, there were significant increase in cell proliferation and modification of HSCs after Hcy treatment. In conclusion, a long term high methionine diet can cause a reduction of BMP-13 in the liver. The reduction of BMP-13 in the liver may contribute to liver injury induced by a high methionine diet.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".