Understanding the role of the cytoskeleton inthe complex regulation of the endothelial repair
Bibliographic record
Abstract
Actin microfilaments and microtubules are \nimportant cytoskeletal proteins that regulate endothelial \nrepair through alterations in cell shape and through \nregulation of cell migration following wounding of the \nendothelium. Upstream pathways have been identified in \nthe regulation of actin and microtubule organization, \nespecially small GTPases. Recently, there have been \nnumerous proteins suggested to be capable of regulating \ninteraction between microtubules and microfilaments to \nmediate microtubule regulation of endothelial repair, an \nimportant process in limiting injury to the artery wall \nand in reducing the extent of arterial disease. If \ndisrupted, a rapid repair mechanism is important in \nreestablishing the integrity of the endothelium in order to \nreestablish its function as a macromolecular barrier, a \nthromboresistant surface, and a biologically active \ntissue. Strategies to improve repair should alter the \npathobiology of the atherosclerotic plaque and thus \nimprove the prognosis of patients with atherosclerosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.004 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".