Altered cerebrovascular proteome in Alzheimer’s disease mice and the effect of pharmacotherapy
Bibliographic record
Abstract
Cerebrovascular insufficiency appears years prior to clinical symptoms in Alzheimer’s disease (AD). The soluble, highly toxic amyloid-beta (Aβ) species, generated from the amyloidogenic processing of amyloid precursor protein (APP), are known instigators of the chronic cerebrovascular hypoperfusion observed in AD patients. To date, the global response of the cerebrovascular proteome to excess soluble Aβ and to pharmacotherapy that normalizes cerebrovascular function remains poorly understood. We previously demonstrated that the anti-diabetic drug pioglitazone, currently in a Phase III trial for delay of AD onset, reverses cerebrovascular impairment in a mouse model of AD overexpressing Aβ (APP mice). In this study, we characterized the effects of soluble Aβ overproduction on the cerebrovascular proteome of mice; determined how pioglitazone-treatment affected the altered proteome; and analyzed the relationship between normalized protein levels and recovery of cerebrovascular function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".