Characterization of the respiratory phenotype of the Late Gestation Lung 1 («Lgl1») heterozygote mouse
Bibliographic record
Abstract
Bronchopulmonary dysplasia (BPD), a disease characterized by an arrest in alveolar development, remains one of the leading causes of morbidity in very low birth weight newborns [1, 2]. Insight into the mechanisms and genes involved in alveolarization could be used to better understand the lung pathophysiology of this disease and help with the development of new treatment interventions. Lgl1, is a developmentally regulated, glucocorticoid induced, secreted glycoprotein in the lung [3]. In O2 toxicity animal models of BPD, Lgl1 levels are reduced and return to normal during recovery in air [4]. To determine if a deficiency of Lgl1 is associated with arrested alveolarization and contributes to the pathophysiology of BPD, an Lgl1 knockout mouse model was created. Lgl1 deficiency revealed a complex phenotype including: goblet cell hyperplasia, mucus production, increase expression of interleukins 4 and 13, disruption of lung development, elastin fragmentation and disruption of lung function suggesting that Lgl1 deficiency may contribute to BPD in the neonatal period.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.003 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".