Induction of «in vitro» and «in vivo» steroidogenesis, through identifying and targeting the negative regulators of this process, 14-3-3y and E
Bibliographic record
Abstract
Canada de reproduire, publier, archiver, sauvegarder, conserver, transmettre au public par telecommunication ou par I'lnternet, preter, distribuer et vendre des theses partout dans le monde, a des fins commerciales ou autres, sur support microforme, papier, electronique et/ou autres formats.L'auteur conserve la propriete du droit d'auteur et des droits moraux qui protege cette these.Ni la these ni des extraits substantiels de celleci ne doivent etre imprimes ou autrement reproduits sans son autorisation.Conformement a la loi canadienne sur la protection de la vie privee, quelques formulaires secondaires ont ete enleves de cette these.Bien que ces formulaires aient inclus dans la pagination, il n'y aura aucun contenu manquant. List of abbreviations8-Br-cAMP……………………………………………………………………8-Bromo-cAMP 19-Atriol…………………………………………...Androstenetriol, 3,17,19-androsten-5-triol 3βHSD…………………………………………………….. 3b-hydroxysteroid dehydrogenase 3-D…………………………………………………...……………………... Three-dimensional AAC…………………………………………….Adenosine nucleotide translocase component ACBD1……………………………………… Acyl-CoA-binding domain-containing protein-1 ACBD3……………………………………... Acyl-CoA-binding domain-containing protein 3 Acryamide gel …………………………………………………………………………...PAGE ACTH………………………………………...………………….Adrenocorticotropin hormone AKAP…………………………………………...………………….A kinase anchoring protein BN-PAGE……………………………………..Blue native polyacrylamide gel electrophoresis CAH……………………………………………..…....... Congenital adrenal lipoid hyperplasia cAMP……………………………………………..…………Cyclic adenosine monophosphate CBP………………………………………………..…………………… CREB binding protein co-IP………………………………………………...…………………Co-immunoprecipitation COX IV……………………………………………...………………… Cytochrome C oxidase CRAC………………………………Cholesterol recognition/interaction amino acid consensus CREB………………………………..………………….Responsive element binding protein 1 CYP11A1……………………………..……….Cytochrome P450 side-chain cleavage enzyme DBI……………………………………..……………………….....
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".