Immediate and delayed suppression of type I interferon induction in porcine immune cells by Nipah virus Malaysia V protein
Bibliographic record
Abstract
Nipah virus Malaysia genotype (NiV-M) is an emerging zoonotic paramyxovirus. The non-structural P gene products of NiV-M (the V and W proteins) have been implicated in the block of type I interferon signaling, but live virus investigations of their roles in the porcine host are lacking. In this investigation, recombinant NiV-M that do not express either the V or W proteins were used to examine the relevance of these proteins to the induction of type I IFN in porcine immune cells. The V protein was found to be important to the production of infectious virus in porcine immune cells by limiting the production of type I IFNs both immediately after entry and later in the infectious cycle. Immunogold electron microscopy (IEM) imaging indicated that the NiV-M V and W proteins are incorporated into the NiV-M virion by attachments to the nucleocapsid. These findings show that the V protein of NiV-M suppresses type I IFN production throughout infection of porcine immune cells and demonstrate a mechanism by which NiV-M modulates the immune response in swine.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".