Immune response of chickens to immunologically-distinct strains of the coccidian parasite Eimeria maxima
Bibliographic record
Abstract
'Eimeria maxima' is a protozoan parasite of the chicken, 'Gallus domesticus'. Recent live oocyst vaccine failures to protect against infection with field isolates of 'E. maxima ' have demonstrated that there are immunologically distinct strains of this species. The immunological basis of this variation was studied for the Guelph and the Florida strains. It was hypothesized that the differences in protection observed would be manifested in the adaptive immune response. To test this, serum antibody and local T lymphocyte involvement in the immune responses during homologous and heterologous infections were evaluated. Minimal differences were detected in the serum IgG antibody responses during challenge infections with the two strains. Increases in the numbers of CD4+ and CD8+ as well as [gamma][delta] TCR+ and [alpha][beta] TCR+ lymphocytes were observed during heterologous challenge suggesting that distinct T-cell epitopes may exist in each strain and could explain the lack of protection observed during heterologous challenge.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".