Maternal use of medication and childhood leukemia
Bibliographic record
Abstract
This thesis explored the association between maternal use of medication during pregnancy and risk of childhood acute lymphocytic leukemia (ALL); specifically, whether use of antibiotics, analgesics, anti-nauseas and/or illicit drugs were associated with an increased risk of ALL in the offspring. All cases of ALL, aged 0--14, diagnosed in Quebec during the period 1994--1997 were identified and matched to population-based controls by age and sex. With an overall response rate of 87%, this resulted in nearly 160 case-control pairs. Information was obtained from parents via telephone interviews, and analyzed using conditional logistic regression. Overall use of medication did not increase risk of childhood ALL (OR = 1.15, 95% CI = 0.66--1.99). Increased risks were observed for illicit drug use in the year prior to birth (OR = 2.44, 95% CI = 0.66--9.00), and for the offspring of women who used pain medication during delivery (OR = 1.88, 95% CI = 1.05--3.31); however, the latter increase was seen for male children only (OR = 3.43, 95% CI = 1.45--8.10).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".