Spontaneous errors of imprinting in mouse embryos
Bibliographic record
Abstract
Genomic imprinting is a mechanism of fine regulation of gene expression. Imprinted genes are expressed from only one parental allele and many of them have critical roles in growth and development. Imprinting marks that distinguish the parental origin must be erased and re-established in germ cells according to the sex of the individual to ensure proper embryonic development. We investigated occurrence of imprinting errors in mouse embryos. Firstly, we tested the hypothesis that errors in resetting of imprints occur and lead to grandparental-origin effects on embryonic growth. Although we did not find statistically significant effects, we observed trends that should be confirmed by replication. Secondly, we examined expression of 5 genes located on the distal part of chromosome 12 in order to establish the incidence of spontaneous imprinting errors. We report a strain and parental-origin specific imprinting relaxation of Dlk1 and Dio3 genes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".