エストロゲンによる異なった受容体を介するマクロファージ様細胞のNa, K-ATPase活性促進作用
Bibliographic record
Abstract
Many types of cells in the monocyte‒macrophage linage have been shown to be regulated by estrogen. In addition, a body of information suggests that the Na, K-ATPase pump could be a target of 17β-estradiol (E2) in various types of cells. In this study, we explored the effects of E2 on the Na, K-ATPase in macrophage-like RAW 264.7 cells. E2 treatment of RAW 264.7 cells led to biphasic stimulation of Na, K-ATPase activity: an early activation via the cell surface receptor GPR30 and a late upregulation by nuclear estrogen receptor (ER)-activated signals. Antagonization of GPR30 by G15 abolished E2-induced early activation of Na, K-ATPase, while inhibition of ER signals nullified its late upregulation of Na, K-ATPase activity in a dose-dependent manner. Furthermore, short-term treatment with E2 induced phosphorylation of the Na, K-ATPase α1- subunit at Tyr-10, which relied on was related to an increase i n the N a＋ affinity of Na, K-ATPase. These results illustrate the involvement of two diffe rent signaling pathways in the regulation of Na, K-ATPase by E2.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".