エストロゲンによる異なった受容体を介するマクロファージ様細胞のNa, K-ATPase活性促進作用
Bibliographic record
Abstract
Many types of cells in the monocyte‒macrophage linage have been shown to be regulated by estrogen. In addition, a body of information suggests that the Na, K-ATPase pump could be a target of 17β-estradiol (E2) in various types of cells. In this study, we explored the effects of E2 on the Na, K-ATPase in macrophage-like RAW 264.7 cells. E2 treatment of RAW 264.7 cells led to biphasic stimulation of Na, K-ATPase activity: an early activation via the cell surface receptor GPR30 and a late upregulation by nuclear estrogen receptor (ER)-activated signals. Antagonization of GPR30 by G15 abolished E2-induced early activation of Na, K-ATPase, while inhibition of ER signals nullified its late upregulation of Na, K-ATPase activity in a dose-dependent manner. Furthermore, short-term treatment with E2 induced phosphorylation of the Na, K-ATPase α1- subunit at Tyr-10, which relied on was related to an increase i n the N a＋ affinity of Na, K-ATPase. These results illustrate the involvement of two diffe rent signaling pathways in the regulation of Na, K-ATPase by E2.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".