Electrical Stimulation of Rhabdomyosarcoma Cells Induces Cell Cycle Arrest and Autophagy
Bibliographic record
Abstract
Rhabdomyosarcoma is a family of rare juvenile cancers that express molecular factors implicated in myogenic differentiation. Cell cycle arrest is absolutely necessary for muscle maturation, while abnormal cell cycle and cell death programs are hallmarks of cancer onset and progression. The cancerous rhabdomyosarcoma cells continue to uncontrollably proliferate in part due to deficiencies in the myogenic program. Electrical stimulation is known to alter the phenotype of myogenic cells, such changes include cell cycle arrest and enhanced myoblast differentiation. Since rhabdomyosarcoma tumors are muscle-like this thesis looks at the use electrical stimulation towards these cells in an attempt to induce differentiation and prevent growth. The results indicate that the response elicited in rhabdomyosarcoma cells following electrical stimulation is different from the one observed in myoblasts, however cell cycle arrest and cell death through autophagy contribute to a large reduction in the number of cells, which represents a potential therapeutic approach.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".