Incidence of New-onset Atrial Fibrillation following Transcatheter Closure of Patent Foramen Ovale in Ontario
Bibliographic record
Abstract
Patent foramen ovale (PFO) has been associated with an increased risk of cryptogenic stroke. Transcatheter closure (TC) is a commonly recommended intervention for PFO for selected patients. Some recent evidence, however, has implicated TC with increasing the risk of new-onset atrial fibrillation (AF) post-closure. This thesis represents a comprehensive evaluation of the risk of AF following PFO closure. First, a systematic review and meta-analysis synthesized current evidence in the literature for new-onset AF in PFO patients following TC. Then, a random forest classification algorithm identified which patients underwent a PFO versus an atrial septal defect (ASD) closure in Ontario administrative database records. Lastly, identified PFO patients were evaluated for incidence of new-onset AF post-closure, which was relatively low. Diabetes and being over age 60 were predictors of post-closure AF in this population. Improvements in consistency of AF monitoring are needed to gauge the true risk of AF following TC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".