Modelos celulares de inmunodeficiencias congénitas de linfocitos T: aplicación a estudios de expresión y señalización
Bibliographic record
Abstract
Los linfocitos T desempeñan uno de los papeles más cruciales en la respuesta inmunológica: la respuesta adaptativa. La activación del linfocito T a través de su receptor, el TCR, desencadena una extensa red de señalización con decenas de proteínas intermediarias diferentes para generar respuestas efectoras adecuadas. El TCR es un complejo octamérico constituido por diferentes cadenas entre las que se encuentra CD247. La ausencia de cualquiera de los componentes del TCR se traduce en un defecto de desarrollo o función de los linfocitos T causante de SCID. Además, en los casos de deficiencias de CD247 se han descrito mutaciones somáticas minoritarias que son capaces de restaurar el defecto de expresión del TCR..
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".