Netrin and netrin receptor expression in the adult rat spinal cord : evidence that myelin-associated netrin-1 is an inhibitor of neurite extension
Bibliographic record
Abstract
The netrins are a family of secreted proteins with a well characterized role in directing migrating cells and axons during embryogenesis. Netrin-1 is also expressed in the adult CNS, although its function in the adult is not known. Characterization of netrin-1 in the adult spinal cord indicated that it is expressed by neurons and oligodendrocytes and that following its secretion, netrin-1 is associated with membranes and extracellular matrix (ECM). Netrin-1 attracts or repels different cell types in the developing CNS. The repertoire of netrin receptors expressed exerts a key influence on the response of a cell to netrin-1. Expression of the netrin receptor DCC, required for an attractive response, decreased during spinal cord development, resulting in barely detectable levels in the adult. Conversely, UNC-5 homologues, required for a repellent response, were expressed in the adult at higher levels than during development. These findings suggested that in the adult spinal cord netrin-1 may function predominantly as a short-range cue that inhibits certain forms of plasticity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".