The role of ZC3H12A in «Pseudomonas aeruginosa» infection of airway epithelial cells and implication in Cystic Fibrosis
Bibliographic record
Abstract
Cystic fibrosis (CF) is the most common fatal genetic disease affecting Canadian Caucasians. The majority of CF patients suffered from perpetual inflammation caused by Pseudomonas aeruginosa (P. aeruginosa). Previous, we found cells lacking functionalCFTR exhibit IL6 hypersecretion phenotype and a concomitant hyperactivity of p38 MAPK in response to P. aeruginosa. Therefore, I dedicated my master's thesis to investigate the link between increased IL6 production and p38 MAPK. ZC3H12A, an IL6-specific ribonuclease, was found to be a novel substrate of p38 MAPK and negatively regulated IL6 production from P. aeruginosa-stimulated airway epithelial cells. Together, these discoveries demonstrated a direct link between a specific signal transduction pathway and am RNA stability modulator, both of which contribute to the regulation of IL6 gene expression at a post-transcriptional level.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".