The role of vitamin D and vitamin D analogues in gene regulation and potentiation of immune response to «Mycobacterium tuberculosis»
Bibliographic record
Abstract
1,25-dihydroxyvitamin D3 (1,25D) is the hormonally active form of vitamin D, a key factor in calcium (Ca2+) homeostasis. 1,25D has also been shown to mediate a number of other physiological mechanisms. Here we pay special attention to the immunoregulatory properties of 1,25D, and its role in stimulating immune responses against pathogenic infection. The innate branch of the immune system is responsible for the rapid, non-specific host response against pathogenic infection. 1,25D induces the expression of antimicrobial peptides, which serve as the vanguards of innate immune response as predicted in vitro by human monocytic (THP-1), as well as intestinal epithelial cell lines (SW480, HT-29). Furthermore, antimicrobial peptides regulate a number of immune responses such as wound healing and cytokine induction. Butyrate is a histone deacetlyase inhibitor (HDI), and a natural constituent of the gut, which is known to possess significant gene regulatory properties, including the induction of antimicrobial peptide expression. The purpose of this study is to investigate how therapy, combining 1,25D with the underlying gene regulation activity of butyrate, may function in stimulating immune responses against infection, particularly with regard to Mycobacteria tuberculosis. Given the potential that either butyrate or 1,25D alone promotes the production of antimicrobial peptides, this combination therapy shows promise in developing a novel approach to treat infection by enhancing antimicrobial gene expression. By modifying the side chain of 1,25D to possess HDI-like properties, it may be possible to develop bifunctional vitamin D analogues with enhanced therapeutic value to be used against mycobacterial infection.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".