TGF-[beta] action in skin cells : regulation by oxygen tension and steroids
Bibliographic record
Abstract
In this era of modern medicine, impaired wound healing is still a major medical problem with limited treatment options, especially for the elderly and for diabetic patients. One of the molecules that are recognized to be critical in wound healing is transforming growth factor (TGF-beta). Exogenous direct application of TGF-beta to the wound promotes healing in animal models. Since this property of TGF-beta is cell context-dependent, the present study investigated the role of ischemia/reperfusion using a pig-skin flap model (in vivo). In addition, we studied the effects of: (i) hypoxia/reperfusion, (ii) steroids, and (iii) the combined effect of both hypoxia and steroids on the TGF-beta signaling pathway (TGF-beta, its receptors and its downstream mediators, Smad2 and Smad3) in vitro; all of these were studied using human primary skin fibroblasts and a human keratinocyte cell line (HaCat cells).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".