Colistin non-susceptible Pseudomonas aeruginosa ST654 with blaNDM-1 arrives in North America
Bibliographic record
Abstract
This study describes 3 different blaNDM-1 genetic platforms in 3 different species obtained from \nthe same patient who was directly transferred to an institution in Calgary, Canada, following a \nprolonged hospital stay in India. The blaNDM-1 in the Escherichia coli was located on a 176kb \nIncA/C plasmid contained within an ISCR1 region. The blaNDM-1 in the Providencia rettgeri was \nlocated on a 117kb IncT plasmid contained within Tn3000, while the blaNDM-1 in Pseudomonas \naeruginosa was located on the chromosome within an ISCR3 region. This report highlights the \nplasticity of the genetic regions and environments associated with blaNDM-1. To the best of our \nknowledge, this is the first report of P. aeruginosa with blaNDM-1 identified in North America and \nthe first report of blaOXA-181in P. rettgeri. The P. aeruginosa belonged to the international high \nrisk clone ST654 and was non-susceptible to colistin. This case emphasizes the need for \nappropriate infection prevention and control measures and vigilant screening for carbapenem \nresistant Gram negative bacteria in patients with a history of travel to endemic areas, such as the \nIndian subcontinent.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".