Characterization of the retinoblastoma binding protein 2 (RBP2)
Bibliographic record
Abstract
The retinoblastoma (RB) family of proteins plays a pivotal role in cell cycle regulation. Its members, p105/Rb, p107 and p130, interact with the E2F and DP family of transcription factors to regulate transcription of essential cell cycle and DNA synthesis genes. Several reports have mapped the regulation of E217 by RB family members to the "pocket" domain of these proteins. We demonstrate here that RBP2, a pocket-binding protein that encodes multiple DNA-binding and protein-protein interaction domains, is a transcriptional repressor. Overexpression of RBP2 inhibits E2F-dependent transcription and inhibits cellular growth. The growth suppression activity of RBP2 could not be associated with a single domain within the protein but the transcriptional repression activity can be mapped to a minimal 17 kDa fragment located at the extreme N-terminus of RBP2 that can repress transcription when expressed alone but requires the C-terminus in the context of the full-length protein.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".