Comparing fatigue induced by isometric and shortening contractions in skeletal muscle
Bibliographic record
Abstract
The intramuscular mechanisms causing greater fatigue-induced reduction in force during shortening compared with isometric contractions is not completely understood. The focus of this thesis was to compare fatigue in repeated shortening contractions and isometric contractions and investigate if greater force loss during repeated shortening contractions is attributed to more severe reductions in sarcoplasmic reticulum Ca2+ release. Single intact flexor digitorum brevis muscle fibres from C57Bl/6 mice were mechanically dissected and loaded with indo-1 AM fluorescent dye to assess myoplasmic free [Ca2+]. Fibres were either placed in an isometric or shortening protocol which were both stimulated at 70Hz of 600ms duration and 4 seconds rest for 50 tetani. The results of this thesis did not show that repeated shortening contractions cause greater fatigue-induced reductions in force compared with repeated isometric contractions, and there were no differences in the fatigue-induced reductions in SR Ca2+ release during the repeated contractions.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".