Cytokine Gene Expression in Holstein-Friesian and Jersey Calves Infected with Mycobacterium avium subsp. paratuberculosis
Bibliographic record
Abstract
Breed susceptibility to bovine Johne’s disease has been implied suggesting that Jersey cattle are more susceptible to disease as compared to Holstein-Friesian. A sixty-day experimental in vivo infection study was carried out by surgically infecting Holstein-Friesian and Jersey calves with the etiological agent of Johne’s disease, Mycobacterium avium subsp. paratuberculosis (Map). Breed-specific comparison of expression of key cytokine transcripts in the ileocecal lymph nodes of Map-infected and uninfected calves by real-time PCR did not indicate any significant differences. The expression of IFN-γ transcript was found to be significantly different for the treatment groups in both breeds with a higher expression level in infected than in control animals but there was no indication this differed between breeds. These data indicate that there are no breed-specific differences in the expression of key cytokine transcripts at sixty days post Map-infection and warrants long-term infection studies to analyze breed-specific immune response and in defining breed susceptibility.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".