Genetic markers of neurodegeneration: a role for paraoconase 1 in sporadic Alzheimer's disease?
Bibliographic record
Abstract
Mounting evidence points to increased oxidative stress and disruption of cholesterol homeostasis as being crucial events implicated in Alzheimer's disease (AD) etiopathology. Paraoxonase1 (PON1) is a high-density lipoprotein-associated antioxidant enzyme that functions to protect both lipids and the cholinergic system, the primary neurotransmitter system affected in AD, from respectively oxidation and organophosphate compounds. Using a large and homogeneous cohort of Quebec citizens, we therefore sought to investigate the involvement of PON1 in AD. We found that a single nucleotide polymorphism (SNP) in the PON1 gene not only exerts an AD risk enhancing effect but also a paradoxical survival rate increasing effect and a later age at AD symptom onset. This SNP is also significantly associated, sometimes in opposite directions for both sexes, with beta-amyloid levels, senile plaque accumulation and choline acetyltransferase activity in numerous brain areas. Thus, these results suggest a prominent role for PON1 in the etiopathology of AD.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".