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Record W7010361024

Identification of the genetic component of host susceptibility to viral infection in mice

2016· dissertation· en· W7010361024 on OpenAlexfundno aff

Bibliographic record

VenueeScholarship@McGill (McGill) · 2016
Typedissertation
Languageen
FieldMedicine
TopicInfluenza Virus Research Studies
Canadian institutionsnot available
FundersUniversity of Ottawa
KeywordsCongenicEctromelia virusQuantitative trait locusGeneVirusCandidate geneIdentification (biology)DiseasePathogen
DOInot available

Abstract

fetched live from OpenAlex

Actc1 -actin, alpha, cardiac muscle Acta2 -actin, alpha 2, smooth muscle ANOVA -analysis of variance B6 -C57BL/6 BALF -bronchoalveolar lavage fluid BG -background C5 -hemolytic complement CSS -Chromosome substitution strain DNA -deoxyribonucleic acid DSO -donor strain of origin ECTV -ectromelia virus EEV -extracellular enveloped virion EMMA -Efficient Mixed Model Association eQTL -expression quantitative trait locus FBS -fetal bovine serum Gapdh -Glyceraldehyde-3-Phosphate Dehydrogenase H&E -hematoxylin and eosin HA -hemagglutinin HPRT -hypoxanthine phosphoribosyl-transferase 1 Ifitm3 -interferon-inducible transmembrane 3 IMV -intracellular mature virion Itgb1 -integrin, beta 1 KC -keratinocyte chemoattractant LDH -lactate dehydrogenase LDL -low-density lipoprotein LOD -logarithm of odds LPS -Lipopolysaccharides Lyso-PC -lysophosphatidylcholine MCP-1 -monocyte chemoattractant protein 1 MHC -major histocompatibility complex MP1 -matrix protein 1 MP2 -matrix protein 2 Mx1 or Mx2 -myxovirus resistance protein Myl7 -myosin, light chain 7 NA -neuraminidase NK -natural killer NLR -NOD-like receptor NP -nucleoprotein NS-1 -non-structural protein 1 NS-2 -non-structural protein 2 OAS -2'5'oligoadenylate synthetase OxPL -oxidized phospholipids PA -polymerase acid PAF -platelet activating factor PAMP -Pathogen-associated molecular pattern PB1 -polymerase basic 1 PB2 -polymerase basic 2 PBS -phosphate buffered solution PCA -principal component analysis PCR -Polymerase chain reaction PFA -paraformaldehyde PFU -Plaque forming units PKR -Protein kinase R Pla2g7 -Phospholipase A2, Group VII PR8 -A/PR/8/34 qPCR -quantitative polymerase chain reaction QTL -quantitative trait locus RCS -recombinant congenic strains RFLP -restriction fragment length polymorphism RMP -Resistance to mousepox RNA -ribonucleic acid RNAse L-ribonuclease L RNP -Ribonucleoprotein SSLP -Simple sequence length polymorphism TNF -Tumor necrosis factor

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0020.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.323
Teacher spread0.292 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2016
Admission routes1
Has abstractyes

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