A multilocus phylogeny of Hericium fungi in Canada and their production of Erinacine A
Bibliographic record
Abstract
The genus Hericium contains species demonstrated to produce bioactive secondary metabolites with potential medical applications. Previous phylogenies of the genus Hericium based on the internal transcribed spacer (ITS) region struggle to support monophyly at the species level, hindering biochemical research efforts. Using concatenated sequence data from ITS, the large ribosomal subunit (LSU), translation elongation factor 1-alpha (tef1) and RNA polymerase subunit 2 (rpb2) genes, Hericium species from North America and key taxa from Europe were resolved as monophyletic groups. Several species of Hericium from North America also demonstrated production of erinacine A, a secondary metabolite with nerve-growth factor stimulatory activity, and liquid culture conditions were modified for enhanced erinacine A biosynthesis in each species. Together with clear distinction of the species in Hericium, the findings presented herein will contribute to natural products research and medical applications of these edible and medicinally valuable mushrooms.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".