The Next Generation Cohort: Childhood Outcomes of Offspring of Parents with Early Onset Type 2 Diabetes
Bibliographic record
Abstract
The Next Generation Birth Cohort has recruited 127 offspring of parents with youth-onset type 2 diabetes (T2DM)since 2003. Despite the high rate of awareness of the risks of obesity and T2DM in the offspring, 66% are obese at the most recent assessment with an average BMI zscore of 1.9, and 34.4% of the offspring age 10 years and older have T2DM. All of the offspring . with T2DM are overweight or obese, all were born to mothers with pre-pregnancy T2DM, and all have 1 or 2 copies ofthe private HNF-l a G319S polymorphism. The size of the cohort remains too small to make conclusions about the impact of the intrauterine environment and the S319 allele on the risk ofT2DM in this highly selected population.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".