The Role of Neutrophils in The Invasive Behaviour of Oral Squamous Cell Carcinoma
Bibliographic record
Abstract
Oral cancers are the 15th leading cause of cancer death in Canada with an overall high mortality rate (Canadian Cancer Society, 2013). A review of the current literature on neutrophils supports a pro-tumour role of neutrophils in oral squamous cell carcinomas (OSCC) but the precise mechanisms still need to be clarified. The interaction between human neutrophils and human oral cancer cell line (UMSCC47) was investigated using quantitative in vitro invasion and matrix degradation assays. Both direct and indirect co-cultures of UMSCC47 and neutrophils increased the invasiveness of cancer cells through and increase in the number of invadopodia and matrix degradation. The results of this study show that neutrophils increase the invasiveness of OSCC through the activation of invadopodia, suggesting that the presence of neutrophils in the oral environment may modulate the clinical behaviour of OSCC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".