Characterization of molecular mechanisms involving the transcriptional repression functions of mammalian Groucho/TLE proteins
Bibliographic record
Abstract
To investigate the molecular mechanisms regulating mammalian neurogenesis, studies were performed that centered on a family of transcriptional co-repressors whose founding member is Drosophila Groucho (Gro). Genetic studies show that Groucho plays fundamental roles in a variety of cell-differentiation events, including neurogenesis. The overall hypothesis of this thesis is that Groucho's mammalian homologues, the t&barbelow;ransducin-l&barbelow;ike E&barbelow;nhancer of split (TLE) proteins, are general transcriptional co-repressors important in regulating a variety of cell differentiation events in mammals. The main goal of these studies was to elucidate the molecular mechanisms underlying TLE function.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".