Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status
Bibliographic record
Abstract
our findings.6 Cyclophosphamide is well known to affect T H 1-mediated disease, but limited data exist for allergic diseases.Interestingly, in our patient, several specific IgEs became undetectable, yet presumably because of the extremely high pretreatment level of milk-specific IgE, this did not abate, and even after HiCy he continued to have food-related anaphylaxis to milk.Although HiCy may reduce total and specific IgE levels for at least 12 months, it may also reset IgE production.Indeed, our patient developed new IgE sensitizations, albeit of unclear clinical significance.Whether the persistence of clinical reactivity is due primarily to the residual amount of remaining milkspecific IgE being produced by long-lived plasma cells, 7 IgE production and its persistence in the mucosa, 8 effects on regulatory T cells 9 or other factors less affected by HiCy cannot be determined.In conclusion, to our knowledge, this is the first case that demonstrates the effect of HiCy on IgE levels in an individual with food and respiratory allergies and demonstrates prolonged and marked suppressive effects on some pre-existing IgE levels along with the appearance of new IgE specificities.At least for milk, his clinical reactivity remained unchanged based on accidental exposures, clearly demonstrating a disconnect between IgE levels and clinical reactivity.How long these changes will persist, and their long-term clinical relevance, remains to be seen.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".