Immunotherapy of allergic disorders in a mouse model of allergic airway inflammation
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
A more serious syndrome is allergic asthma, which is triggered by allergen-induced activation of submucosal mast cells in the lower airways (Janeway et al., 2001).Allergic asthma is a chronic inflammatory disease of the respiratory tract with rising incidence and prevalence in industrial countries.According to the World Health Organization, asthma affects 150 million people worldwide and is the most prevalent chronic disease of childhood (Epstein M., 2004).Asthma morbidity and mortality have increased over the last two decades, particularly in western countries (Beasley et al., 2000).Among children, higher prevalence rates have been found in industrialized Western countries than in developing countries in Asia and Africa (Beasley et al., 2000).In the Middle East, asthma prevalence is reported to be lower than in developed countries (Behbehani et al., 2000).The International Study of Asthma and Allergies in Childhood (ISAAC) was the first study carried out worldwide using standardized questionnaires in order to create a reliable global map of childhood allergy.They studied 257.800 children aged 6 to 7 years in 38 countries, and 463.801 children aged 13 to 14 years in 56 countries including Europe, Asia, Africa, Australia, North and South America.The prevalence of rhinitis with itchy-watery eyes (rhinoconjunctivitis) in 1996 varied across centres from 0.8 -14.9% in the 6-7 year-olds and from 1.4 -39.7% in the 13-14 year-olds (Strachan et al., 1997).Wheezing prevalence (indicative of asthma) ranged from 4.1 to 32.1% in the younger age group and from 2.1 to 32.2% in the older age group and was particularly high in English speaking countries and Latin America (Asher and ISAAC Committee, 1998).Allergic asthma is a common medical problem faced by emergency units and intensive care specialists.Data from Australia, Canada and Spain have reported that allergic asthma accounted for 1 to 12% of all adult emergency visits (Rodrigo et al.,2004).It is estimated that there are 18 asthma-related deaths per million people and 180,000 deaths per year (WHO, 2000).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it