Lipid interactions with the cardiac NaS+-HS+ exchanger
Bibliographic record
Abstract
Cardiac sarcolemmal Na+-H+ exchange is critical for the regulation of intracellular pH and its activity contributes to ischemia/reperfusion injury. It also plays an important role during ischemia/reperfusion injury in diabetics. The Na+-H + exchanger is altered during insulin-dependent diabetes mellitus, however, the mechanism for this inhibition has yet to be determined. Coincidentally, the cardiac sarcolemmal membrane phospholipids are also altered during insulin-dependent diabetes mellitus. It has been suggested that the membrane phospholipid environment does not modulate Na+-H+ exchange. The present study was carried out to determine the effects on Na+-H + exchange of modifying the endogenous membrane phospholipids through the addition of exogenous phospholipase AZ, phospholipase C, phospholipasase D, specific phospholipids and saturated and unsaturated fatty acids. The effects on Na+-H+ exchange of a direct addition of specific lipids to the sarcolemmal membrane was investigated. 22Na was utilized asa tracer to determine the amount of H +-dependent Na+ uptake. This study demonstrates that specific alterations in the cardiac sarcolemmal membrane phospholipids influence the activity of the Na+-H+ exchanger. (Abstract shortened by UMI.)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".