Structural and functional alterations within the testis and epididymis of the Follitropin Receptor Knockout (FORKO) mouse
Bibliographic record
Abstract
Follicle stimulating hormone (FSH) acting on Sertoli cells of the testis plays important roles during reproductive development. FSH-R knockout (FORKO) mice provide a model to examine alterations in testicular and epididymal structure and function in its absence. Examination of the FORKO testis revealed a gross alteration of Sertoli cell structure indicative of a fluid imbalance. Functional parameters, such as ABP secretion were also significantly reduced in FORKO testis. Morphometry revealed quantitative reductions in seminiferous tubule size. The epididymal epithelium, appeared abnormal and morphometry revealed that epididymal tubule size was reduced in the knockout. Computer Assisted Sperm Analysis on sperm from the cauda epididymidis revealed significant alterations in parameters corresponding to sperm motility as well as sperm counts. These data suggest an important role for the FSH receptor on Sertoli cell structure and functions and on epididymal epithelial size and functions in relation to sperm motility.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".