Alternative mechanisms to generate short CDPCux isoforms in cancer cells
Bibliographic record
Abstract
CDP/Cux is a transcription factor involved in the control of cellular differentiation and proliferation. It contains four DNA binding domains, three Cut Repeats (CR) and a Cut homeodomain (HD). The full-length p200 protein makes an unstable interaction with DNA via CR1CR2 and is responsible for the CCAAT displacement activity of CDP/Cux. A more stable DNA binding activity could also be detected. This particular activity increased as cells progress from G1 to S phase of the cell cycle following two events. One event is the dephosphorylation of CR3HD by the by the cdc25A phosphatase. The other event involves the proteolytic processing of the full length CDP/Cux protein into a p110 isoform. At the transcriptional level, the p110 protein is able to repress the P21waf1/ Cip1 gene promoter and to activate the DNA polymerase alpha gene promoter as well as other S phase specific genes. In human uterine leiomyomas, an increase in the steady state levels of p110 was observed compared to the normal surrounding myometrium.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".