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Record W7028869704

Glutamatergic signaling in oligodendrocyte progenitors

2002· dissertation· en· W7028869704 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueeScholarship@McGill (McGill) · 2002
Typedissertation
Languageen
FieldSocial Sciences
TopicGerman Security and Defense Policies
Canadian institutionsnot available
FundersNational Institute of Mental HealthMedical Research CouncilMultiple Sclerosis SocietyMedical Research Council CanadaMultiple Sclerosis Society of Canada
KeywordsOligodendrocyteGlutamatergicSignal transductionProgenitor cellOrder (exchange)
DOInot available

Abstract

fetched live from OpenAlex

The excitatory neurotransmitter, glutamate, plays an important role in synaptic transmission, brain development and plasticity as well as excitotoxicity. The biological functions of glutamate in neurons are mediated by ion channel-gated or G-protein-coupled receptors that are also located on glial cells, including oligodendrocytes. However, the functions of glutamate receptors in oligodendrocytes and their progenitors remain unknown. The objective of work presented in this thesis was to characterize the effects of glutamate on oligodendrocyte progenitors and the intracellular signaling pathways involved in mediating these effects.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Science and technology studies, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.753
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0020.000
Scholarly communication0.0000.001
Open science0.0010.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.274
Teacher spread0.250 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it