ID1 Expression in Glioblastoma Cells Correlates with One-carbon Mediated Purine Synthesis
Why this work is in the frame
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Bibliographic record
Abstract
Glioblastoma is the most common primary brain tumour in adults. Inhibitor of DNA-binding-1 (ID1) is a transcriptional regulatory protein and a regulator of tumourigenesis in glioblastoma. While ID1 was shown to regulate metabolism in other cancer types, the role of ID1 in metabolic reprogramming of glioblastoma is not clear. In this thesis, we identify a correlation between ID1 expression and 1-C-mediated de novo purine synthesis in glioblastoma, and present data in support of a hypothesizes that this metabolic phenotype underlies proliferative capacity and TMZ-resistance of ID1-high glioblastoma cells. The expression of one-carbon (1-C) metabolism and purine synthesis enzymes are significantly reduced with ID1 knockout. Exogenous purine supplementation restores proliferation in ID1-deficient cells. Treatment of temozolomide-resistant glioblastoma cells (U251-TR) with AICAR sensitizes these cells to chemotherapy. Our data suggest that the metabolic phenotype observed in ID1-high treatment-resistant glioma cells is a potential therapeutic target for this cell population.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it