Investigation of the neuroprotective effects of Haskap berry (Lonicera caerulea) extract on Caenorhabditis elegans
Bibliographic record
Abstract
Alzheimer’s Disease (AD) is the most common form of neurodegenerative dementia in Canada. Many researchers are investigating therapeutic options for the prevention and treatments of AD using natural plant-based sources i.e. superfoods.Haskap berries (HBs) (Fig. 1) are originally native to Siberia and northeastern Asia but have recently expanded to the Canadian market.The compounds found in HBs, such as the anthocyanin cyanidin-3-glucoside (C3G), have demonstrated in purified in vitro studies to have beneficial effects on lifespan, development, and neuronal growth. Research goals of this project are to continue previous work into the investigation of the effects of Haskap Berry Extract (HBE) on C. elegans and determine if HBE has neuroprotective effects in C. elegans, in terms of delaying the onset of phenotypic symptoms, and reducing the accumulation of Aβ plaques.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".