Bibliographic record
Abstract
Atypical myopathy is a pasture-associated syndrome characterised by the sudden onset of acute rhabdomyolysis apart from any exercise. This frequently fatal acquired condition is intimately linked with the environment. Atypical myopathy occurs primarily in autumn in Europe and Midwestern United States (Finno et al. 2006) (van Galen et al. 2011a) but outbreaks have also been reported in spring (Votion et al 2003; van Galen et al. 2011a). Atypical myopathy appears to be specific to horses and to the author’s knowledge no other grazing livestock has been confirmed for the disease. In recent years, atypical myopathy has been recognized as an emergent disease (Votion and Serteyn 2008; van Galen et al. 2010). Lately, major advances have been made in the understanding of the pathophysiology of the condition (Cassart et al. 2007; van der Kolk et al. 2010) and causative hypothesis (Unger-Torroledo et al. 2010). The metabolic defect occurring in atypical myopathy affected horses is a multiple acyl-CoA dehydrogenase deficiency (MADD), which affects mitochondrial fatty acid energy metabolism but not the use of carbohydrates for energy supply (van Galen et al. 2008; Westermann et al. 2008). The development of atypical myopathy is probably multifactorial but the condition has been associated with Clostridium sordellii lethal toxin (Unger-Torroledo et al. 2010). However, no specific treatment of the condition exists and the most effective way of controlling the disease is prevention that includes specific management practices at the horse and pasture levels. This review summarises the latest knowledge about atypical myopathy and provides practical information to prevent the disease.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.003 | 0.004 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".