Role of Peroxisome Proliferator-activated Receptor γ (PPARγ), Pulmonary Blood Flow and Oxygen Delivery in the Regulation of Surfactant Maturation in the Fetal Lung
Bibliographic record
Abstract
At birth, the fetal lung must be mature enough for the fetus to survive the transition to an air-breathing environment. This requires reduction of surface tension at the air-liquid interface to prevent alveolar collapse, achieved by production of surfactant. One factor regulating surfactant production is peroxisome proliferator-activated receptor-γ (PPARγ). This thesis examines the effect of intrafetal rosiglitazone (RGZ; a PPARγ agonist) and leptin administration on surfactant maturation in sheep. In addition, the effect of maternal late gestation undernutrition (LGUN) on surfactant maturation, pulmonary blood flow (PBF) and oxygen delivery (DO2) is investigated. Our findings suggest that there is no effect of RGZ or LGUN on PPARγ signaling or surfactant maturation, whereas leptin infusion increases PPARγ and decreases surfactant protein (SFTP)-B expression in the fetal lung. An additional novel finding is the negative correlation between PBF and DO2 with SFTP-B mRNA expression in late gestation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".