Synthesis and regulation of gurken mRNA in the Drosophila germline
Bibliographic record
Abstract
Asymmetric localization of messenger RNA (mRNA) is a post-transcriptional means of regulating gene expression. It is an important mechanism used early in development by a wide range of organisms to convert cellular asymmetry into complex patterns of cell fate. Some of the best-known examples of asymmetric transcript localization occur during the formation of the egg in Drosophila melanogaster. For example, during mid-oogenesis gurken mRNA, which encodes the Drosophila homologue of the vertebrate Transforming growth factor alpha (TGF-alpha), becomes asymmetrically localized to the presumptive dorsal anterior region of the oocyte. Localized gurken mRNA is translated, resulting in local activation of the Drosophila Epidermal growth factor receptor (EGFR) to establish the oocyte dorsal-ventral axis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".