Cytotoxic effects of 3-methylindole on alveolar epithelial cells and macrophages: with special reference to \nmicrotubular and filamentous assemblies in alveolar \ntype I cells of bovine lung
Bibliographic record
Abstract
The alveolar type I cell is a major \npermeability barrier between the pulmonary interstitium \nand alveolar spaces and its thin cytoplasmic processes are \ngreatly susceptible to injury. These cells are often \nobserved to undergo progressive vesiculation, \nvacuolization and desquamation during 3-methylindole \n(3MI)-induced acute pulmonary edema after oral \nadministration in goats and cattle. The present study \ndescribes proliferation of SER and the presence of \npolymerized tubulin in the form of microtubules \narranged in large bundles shown at ultrastructural level \nas well as with immunofluorescence staining for tubulin \nin alveolar type I cells 72 hours after 3MI treatment. Such \nchanges were not seen in pulmonary endothelial cells, \nalveolar type I1 cells, alveolar macrophages and \nneutrophils. The possible role of microtubules in \nalveolar type I cell as a mechanistic support to resist \ndisruption against the forces of interstitial and alveolar \nedema is compared with alveolar type I1 cells, alveolar \nmacrophages and neutrophils. The latter cells undergo \ndynamic movements in response to inflammatory stimuli \nand therefore did not show microtubules in their cytoplasm
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".