Discovery of novel genetic modulators of response to cytarabine and immune evasion in acute myeloid leukemia
Bibliographic record
Abstract
Definition 2-HG 2-hydroxyglutarate 2'-O-Me rRNA 2'-O-methylation 5-Aza-C Azacytidine 5mC 5-methylcytosine ABL Abelson murine leukemia gene ALDH Aldehyde dehydrogenase ALL Acute lymphoid leukemia AML Acute myeloid leukemia AMP Adenosine monophosphate APL Promyelocytic leukemia Ara-C Cytarabine Ara-U Uracil Arabinoside ARCH Age-related clonal hematopoiesis ARG Arginase ASXL1 Additional sex combs like transcriptional regulator 1 ATM Ataxia-telangiectasia-mutated ATO Arsenic trioxide ATP Adenosine triphosphate ATP Adenosine triphosphate ATR Ataxia telangiectasia and rad3 related ATRA All-trans retinoic acid BCL-2 B-Cell lymphoma 2 BCR Breakpoint cluster region gene BER Base excision repair BM Bone marrow BME Bone marrow microenvironment BMN Bone marrow niche BrdU Bromodeoxyuridine CBF-AML Core-binding factor complex AML CBFB/MYH11 Core-binding factor subunit beta/myosin heavy chain CDA Cytidine deaminase CDP Cytidine diphosphate CEBPA CCAT/enhancer binding protein CEBPE CCAAT Enhancer Binding Protein Epsilon CH3 Methyl groups viii CHIP Clonal hematopoiesis of indeterminate potential CLP Common lymphoid progenitors CMP Chronic myeloid leukemia CMP Common myeloid progenitors CNTs Concentrative nucleoside transporters CR Complete remission CREB CAMP response element-binding protein CRISPR Clustered regularly interspaced short palindromic repeats CRISPRa CRISPR activation CRISPRi CRISPR interference CTP Cytidine triphosphate dCAS9 Endonuclease dead Cas9 DCK Deoxycytidine kinase DDR DNA damage response DGK Deoxyguanosine kinase dhmC 5-hydroxymethylcytosine DNMT3A DNA (cytosine-5)-methyltransferase 3A dNTP Deoxynucleotides DSB Double strand break dsDNA Double strand DNA DUBS Deubiquitinating enzymes E1 Ub-activating enzymes E2 Ub-conjugating enzymes E3 Ub-ligating enzymes ELN European LeukemiaNET ENT Equilibrative nucleoside transporter ET Essential thrombocythemia ETC Electron transport chain EVs Extracellular vesicles EZH2 Zeste 2 polycomb repressive complex 2 subunit FAB French-American-British FACS Fanconi anemia FACS Fluorescence-activated cell sorting FISH Fluorescent in situ hybridization FLT3 Fms-like kinase 3 FLT3-ITD FLT3-Internal Tandem duplication GEMMs Genetically-engineered mouse models GMP Granulocyte-monocyte progenitors GMP Guanosine monophosphate H2O2 Hydrogen peroxide Galicia-Vazquez, William Poon, Steven Findlay, Joey Heath, Vincent Luo for their collaborative efforts, support, and thought-provoking discussions.You guys are the best, and my thesis would have not been possible without you all.Furthermore, I would like to acknowledge the assistance provided by the staff and resources of the Lady Davis
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".