Effects of Maternal High Fat Diet and Milk-derived Exosome Supplementation on DNA Methyltransferase 1
Bibliographic record
Abstract
Maternal high fat diet (mHFD) exposure during perinatal life shapes offspring’s neurodevelopment trajectories. mHFD also influences the bioactive composition of maternal milk, including milk-derived exosomes (MDEs), nanovesicles that transport functional microRNAs (miRNA). miRNA-148/152 regulate DNA methyltransferase-1 (DNMT1), enzyme that catalyzes DNA methylation modifications, which in turn downregulates fat-mass and obesity-associated (Fto) gene via promoter hypermethylation. The main objectives of this thesis were: 1) examine the effects of mHFD exposure on DNMTs and Fto expressions in postnatal day 7 rats and 2) investigate MDE-supplementation effects on DNMTs and Fto expressions using a human microglia cell line. DNMT1 and Fto transcript abundances remained unchanged in the PVN and ventral hippocampus but decreased in the retroperitoneal fat of mHFD offspring. In microglia, MDE-supplementation resulted in increased DNMT1 expression only. These findings indicate that DNMT1 and Fto exhibit tissue-specific sensitivity to mHFD exposure in neonates, and that DNMT1 is altered by MDE-supplementation in microglia.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".