The effect of hydrogen sulfide on glycolysis-based energy production and mouse red blood cell survival
Bibliographic record
Abstract
Hydrogen sulfide (H2S), a gasotransmitter that modulates physiological and pathophysiological \nprocesses, has recently been shown to promote aerobic energy production in the mitochondrion \nin response to hypoxia. Its effect on anaerobic energy production, however, has yet to be \nestablished. Glycolysis is the anaerobic process by which ATP is produced through the \nmetabolism of glucose. The purpose of this study was to establish the effect of H2S on \nglycolysis-mediated energy production in mouse RBCs, which are mitochondrion-free. This \nstudy demonstrated the capacity of mouse RBCs to produce H2S via 3-mercaptopyruvate \nsulfurtransferase (MST). Both exogenously administered H2S salt (NaHS) and MST-derived \nendogenous H2S stimulated glycolysis-mediated ATP production. The effect of NaHS on ATP \nlevels was oxygen-independent. However, hypoxic stress stimulated MST activity in mouse \nRBCs. High concentrations of NaHS (300-1000 μM) prolonged cell viability but reduced ATP \nlevels. H2S may offer a cytoprotective effect in mammalian RBCs to maintain oxygenindependent energy production.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".