Genetic risk factors for suicide in major depression : a focus on the serotonin transporter and tryptophan hydroxylase-2 genes
Bibliographic record
Abstract
Growing evidence suggests a partial genetic determination of suicide predisposition, with most studies focusing on serotonergic genes. Inconsistent results have characterized the serotonin transporter (5-HTT) gene, whereas few studies have investigated the recently discovered brain specific tryptophan hydroxylase 2 (TPH2) gene. At the same time, most of these studies have not controlled for associated psychopathology, an important confounder. Therefore, association studies were conducted to investigate the role of the 5-HTT and TPH2 genes in suicide susceptibility in the context of major depression and their effect on impulsive-aggressive behaviors (IABs), a possible intermediate phenotype. Finally, suicide predictors were investigated while controlling for genetic, clinical and behavioral risk factors. Certain 5-HTT and TPH2 genetic variants were significantly implicated in the vulnerability to suicide, however, no effect on levels of IABs was observed. Genetic and clinical suicide predictors were identified while controlling for other risk factors. Further studies in larger samples are necessary to replicate these findings and detect possible small genetic effects.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".