Health-Related Quality of Life in Children with Spinal Muscular Atrophy
Bibliographic record
Abstract
Spinal Muscular Atrophy (SMA) is a genetic disorder characterized by weakness and muscle atrophy. Due to the chronic nature of SMA, it is important to understand the health-related quality of life among children affected by this disease. Participants were recruited from the Canadian Neuromuscular Disease Registry, where 45 families completed the Pediatric Quality of Life Inventory questionnaires. Results from the child self-report and parent proxy questionnaires were compared to those of healthy children and children with Duchenne Muscular Dystrophy. Agreement between parents and children was assessed using paired t-tests and intraclass correlation coefficients. Additionally, multivariable linear regressions were used to determine child and family characteristics associated with health-related quality of life outcomes. Higher levels of perceived fatigue were consistently associated with lower health-related quality of life outcomes. Based on the results, interventions to reduce fatigue could lead to improvement of health-related quality of life for children with Spinal Muscular Atrophy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".